Are there any limits on the investments I can make via my self-directed IRA account?

The vast majority of start-up investments on AngelList can be made using a self-directed IRA account from the service provider of your choice. Some restrictions do apply, however.

You cannot use your self-directed IRA for certain prohibited transactions, such as investments in start-ups controlled by you or your family. You are responsible for determining your eligibility to make any investment through a self-directed IRA, and you should consult with your tax adviser before making investment decisions using IRA funds.